Administration of Carbon Black (CB) suspensions through the nose of mice causes inflammation of the olfactory nerve.


It was shown in animal experiments that different types of nanoparticles instilled in the trachea can get into the lung’s blood vessel system. Once in the blood, these nanoparticles can pass the blood-brain barrier to get into the brain tissue and trigger inflammatory reactions. Nanoparticles passing the blood-brain barrier have also been shown in a tissue model.

According to an in vivo study with mice, nanoscale carbon black particles instilled in the nose can induce inflammation markers in the olfactory nerve. The authors assume that the particles are taken up in the olfactory mucous membrane in the upper part of the nose by ends of the olfactory nerve and are transported into the brain where microglial cells, the macrophages of the brain, are activated and then release inflammation markers. No inflammation markers were detected, however, in other areas of the brain such as the hippocampus[1].


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  1. Tin Tin Win, S et al. (2006), Toxicol Lett, 163(2): 153-160.


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