After inhalation or instillation of uncoated copper or copper oxide nanoparticles no translocation was observed so far [1,2].

 

The determination of translocation across the air blood barrier is difficult for soluble particles since the dissolution of the particles may occur faster than the time point of analysis. However, as shown in the study of Zhang and coworkers, an increased level of copper ions was measured in liver, lung and olfactory bulb after inhalation of 40 mg/kg mice [2] indicating that at least the released copper ions were able to cross biological barriers.

 

 

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