Tests on rats have shown that non-functionalized Fullerenes cause only a transient inflammatory reaction in the lung and liver.

 

Independent of inhaled or instilled non-functionalized fullerenes in rats, the particles induced only a transient inflammation reaction in the lung. Low doses of ingested fullerenes have the same transient effect in the liver and lung, but not in the gastro-intestinal tract [1-8].

A pretreatment with fullerenes prevented a poisoning reaction in the liver of the test animals with carbon tetrachloride due to the ability of fullerenes to bind free radicals [2].

The solubility and biological effects are changed drastically through functionalization of the surface of C60, for example via hydroxyl groups or other functional groups. Depending on the modification, the suspension procedure or the application of fullerenes, different toxicological outcome are observed, which cannot always be compared directly.

 

 

Literatur arrow down

  1. Sayes, CM et al. (2007), Nano Lett, 7(8): 2399-2406.
  2. Gharbi, N et al. (2005), Nano Lett, 5(12): 2578-2585.
  3. Morimoto, Y et al. (2010) P&FT 7:4
  4. Fujita, K et al. (2009) Toxicol 258:47-55
  5. Fujita, K et al. (2010) Toxicol 274:34-41
  6. Park, EJ et al. (2010) TAAP 244:226-233
  7. Folkmann, JK et al (2009) Environ Health Persp 117(5)703-708
  8. Kadoya, C et al (2016), Nanotoxicol, 10(2):194-203

 

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