The uptake and localization of silicon dioxide particles in cells can be shown by means of electron microscopy.


During in vitro studies, quartz particles are taken up into the cytoplasm of the cells through endocytosis and are enclosed by membranes. No particles were detected in cell compartments such as the cytoblast (which contains the DNA) [1]. Moreover, amorphous particles were observed to accumulate in the cells in vesicles (which, among other things, serve to digest molecules in the cell) but were found not to cause other structural changes in the cell [2]. The amorphous particles are recognized as foreign matter.




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