{"id":14383,"date":"2021-02-16T13:59:34","date_gmt":"2021-02-16T13:59:34","guid":{"rendered":"https:\/\/nanopartikel.info\/?post_type=glossary&#038;p=14383"},"modified":"2021-12-14T13:41:39","modified_gmt":"2021-12-14T12:41:39","slug":"frustrated-phagocytosis","status":"publish","type":"glossary","link":"https:\/\/nanopartikel.info\/en\/glossar\/frustrated-phagocytosis\/","title":{"rendered":"Frustrated phagocytosis"},"content":{"rendered":"<p>Takes place when the process of <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Phagocytosis&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Greek &amp;lt;em&amp;gt;phagein&amp;lt;\/em&amp;gt; - to eat. Mechanism of uptake from particles to small cells in a single eukaryotic cell. Usually, particles are taken up by the cells as membrane-bound aggregates, i.e. large aggregates in vesicles, vacuoles or lamellar bodies (cell compartments surrounded by membranes) through phagocytosis. In mammals, phagocytosis is performed mainly by special cells of the immune system, including the macrophages, monocytes (precursor cells of macrophages), and neutrophils (or neutrophilic granulocytes, belonging to the white blood cells). This uptake is an active, regulated process.&lt;\/div&gt;\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'>phagocytosis<\/span> is disturbed or prevented because the particles or fibres are too large or too long for uptake by the macrophages. The <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Macrophage&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Greek &amp;lt;em&amp;gt;makros&amp;lt;\/em&amp;gt; - large and &amp;lt;em&amp;gt;phagein&amp;lt;\/em&amp;gt; - eat. Big eaters, cells of the immune system serve to eliminate microorganisms or particles by phagocytosis; especially in areas of inflammation.&lt;\/div&gt;\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'>macrophage<\/span> &ldquo;chokes&rdquo; on such particles and dies. At the same time triggering an inflammatory process that can become <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Chronic&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Denotes a slowly occurring or long-lasting effect (e.g. toxic effects occurring only after long exposure time or a protracted inflammation).&lt;\/div&gt;\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]'>chronic<\/span> and lead to disease (fibrosis, tumour)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Takes place when the process of phagocytosis is disturbed or prevented because the particles or fibres are too large or too long for uptake by the macrophages. The macrophage &#8220;chokes&#8221; on such particles and dies. At the same time triggering an inflammatory process that can become chronic and lead to disease (fibrosis, tumour)<\/p>\n","protected":false},"author":3,"featured_media":0,"menu_order":0,"template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/glossary\/14383"}],"collection":[{"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":5,"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/glossary\/14383\/revisions"}],"predecessor-version":[{"id":18389,"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/glossary\/14383\/revisions\/18389"}],"wp:attachment":[{"href":"https:\/\/nanopartikel.info\/en\/wp-json\/wp\/v2\/media?parent=14383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}