NanoBEL

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NanoBEL – Biological Elimination of Complex Diagnostic Nanoparticles

NanoBEL medical applications (c) NanoBEL Consortium

NanoBEL medical applications (c) NanoBEL Consortium

 

Nanotechnology is one of the key technologies of the 21st century that developed from a basic research to a worldwide important discipline in the last years with an enormous importance in life sciences and medicine. Magnetic nanoparticles play an important role in diagnostic imaging for prevention, therapeutic monitoring and therapy.

Whereas the toxicological effects of acute nanoparticle expositions were widely described in the last years, long-term risks depending on the structure of the nanomaterials and the disease state of the patients have not been systematically investigated.

NanoBEL is focused on the risk assessment of the long-term effects of magnetic nanoparticle exposition particularly after repeated administrations, as well as the role of degradation and elimination in the life-cycle of the nanoparticles in diseases like cancer and inflammation. Innovative magnetic nanoparticle formulations with a high relevance for future diagnostic applications are taken into consideration. Beside the development and optimization of magnetic nanoparticles,

NanoBEL contributes to the development and validation of new alternatives to animal-based methods (cell cultures, hen’s egg models) to be applied in an integrated safety assessment of the long-term administration of nanoparticles. In close collaboration with DaNa2.0, the systematic collection of the data in a data base accomplish the categorization of nanomaterials, the identification of relevant endpoints, and the risk management.

 

 

 

 

 


Grant Number: BMBF - FKZ 03XP0003
Duration: 01.05.2015 - 30.04.2018 (verlängert bis 31.08.2018)

Project Lead

Chemicell GmbH Logo
Christian Bergemann, Chemicell GmbH

Project Partners

Chemicell GmbH Logo
Chemicell GmbH, Berlin (DE)
Dyomics GmbH Logo
Dyomics GmbH, Jena (DE)
MicroMod Partikeltechnologie Logo
micromod Partikeltechnologie GmbH, Rostock (DE)
Friedrich-Schiller Universität Jena Logo
Institute of Pharmacy, Friedrich Schiller University Jena, Jena (DE)
Friedrich-Schiller Universität Jena Logo
Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Jena (DE)
Universitätsklinikum Jena Logo
Department of Radiology, Jena University Hospital, Jena (DE)
Universitätsklinikum Jena Logo
Department of Haematology and Medical Oncology, Jena University Hospital, Jena (DE)
Universitätsklinikum Jena Logo
Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena (DE)
Universitätsklinikum Jena Logo
Institute of Pathology, Jena University Hospital, Jena (DE)
IPHT Jena Logo
Leibniz Institute of Photonic Technology (IPHT), Jena (DE)
Fraunhofer IKTS Logo
Fraunhofer Institute for Ceramic Technologies and Systems (IKTS), Dresden (DE)
Universitätsmedizin Mainz Logo
Molecular and cellular oncology, Mainz University Medical Center (UMM), Mainz (DE)

Publications

2017

  • Fischer, D. & Rabel M. (2017). Crack the Egg - Ein alternatives Konzept zur Testung von Nanomaterialien. LABO online, Ausgabe 09/2017, pp.52-55, ISSN 0344-5208. (PDF, 820 KB)
  • Fischer, D. & Warncke, P. (2017). Nano ist nicht gleich nano. Pharmazeutische Zeitung online, Ausgabe 23/2017
  • Schlenk F., Werner S., Rabel M., Jacobs F., Bergemann C., Clement J.H., Fischer D. (2017). Comprehensive analysis of the in vitro and ex ovo hemocompatibility of surface engineered iron oxide nanoparticles for biomedical applications. Arch Toxicol, 91, pp. 3271–3286
 

2016

  • Feliu N., Docter D., Heine M., Del Pino P., Ashraf S., Kolosnjaj-Tabi J., Macchiarini P., Nielsen P., Alloyeau D., Gazeau F., Stauber R.H., Parak W.J. (2016). In vivo degeneration and the fate of inorganic nanoparticles. Chem Soc Rev, 45(9): 2440-2457.
  • Westmeier D., Stauber R.H., Docter D. (2016). The concept of bio-corona in modulating the toxicity of engineered nanomaterials (ENM). Toxicol Appl Pharmacol, 299 53-57.
 

2015

  • Gao Z., Ma T., Zhao E., Docter D., Yang W., Stauber R.H., Gao M. (2015). Small is Smarter: Nano MRI Contrast Agents - Advantages and Recent Achievements. Small
  • Setyawati M.I., Tay C.Y., Docter D., Stauber R.H., Leong D.T. (2015). Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood. Chem Soc Rev, 44(22): 8174-8199.
  • Docter D., Westmeier D., Markiewicz M., Stolte S., Knauer S.K., Stauber R.H. (2015). The nanoparticle biomolecule corona: lessons learned - challenge accepted? Chem Soc Rev, 44(17): 6094-6121.
 

2018

  • Demut, J.; Haist, M.; Rabel, M.; Grüttner, C.; Müller, F.; Quaas, R.; Hochhaus, A.; Fischer, D.; Clement, J.H. (2018). Nanoparticle-Cell Interaction – Surface chemistry triggers inflammation response. 12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, 22.-26. May 2018, Copenhagen, Denmark. [Poster]
  • Fischer, D. (2018). A test concept for the preclinical development of nanomedicines. 9th International Congress Nanotechnology in Biology & Medicine, 25.-27. April 2018, Graz, Austria. [Oral]
  • Weyell, P.; Beekmann, U.; Rabel, M.; Fischer, D.; Demut, J.; Grüttner, C.; Kurland, H.D.; Müller, F.A.; Bergemann, C.; Cialla-May, D.; Vornberger, A.; Kralisch, D. (2018). Safe-by-Design Decision Making Concept for Sustainable Innovation in Nanomedicine. 11th PBP World Meeting, 19.-22. March 2018, Granada, Spain. [Poster]
  • Rabel, M.; Warncke, P.; Kurland, H.-D.; Bergemann, C.; Grüttner, C.; Cialla-May, D.; Müller, F.A.; Fischer, D. (2018). A preclinical test concept for nanomedicines to simulate their life cycle, 11th PBP World Meeting. 19.-22. March 2018, Granada, Spain. [Poster]
  • Fischer, D. (2018). Introduction to Nanomaterials. Nano and Micro Formulations - Bringing together Science, Authority and Industry. 13.-14. March 2018, Berlin, Germany. [Oral]
  • Fischer, D. (2018). Simulations of the degradation of magnetic nanoparticles in biological fluids. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany. [Oral]
  • Clement, J.H.; Demut, J.; Scheerer, P.; Jörke, C.; Hochhaus, A. (2018). Magnetic nanoparticle degradation in in vitro models – Prerequisites and perspectives. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany. [Oral]
  • Kralisch, D.; Weyell, P.; Beekmann, U. (2018). Process Evaluation. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany [Oral]
  • Demut, J.; Scheerer, P.; Grüttner, C.; Bergemann, C.; Müller, F.; Czerney, P.; Hochhaus, A.; Clement, J.H. (2018). Differentially charged SPIONs interfere with inflammation response during interaction with tumor cells. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany. [Poster]
  • Demut, J.; Gräfe, C.; Hochhaus, A.; Clement, J.H (2018). Multicellular spheroids: A model for nanoparticle-tumor cell interaction studies. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany. [Poster]
  • Rabel, M.; Warncke, P.; Thamm, J.; Kurland, H.-D.; Bergemann, C.; Grüttner, C.; Cialla-May, D.; Müller, F.A.; Fischer, D. (2018). Simulating the Life Cycle of Magnetic Iron Oxide Nanoparticles. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany. [Poster]
  • Warncke P.; Rabel, M.; Müller, R.; Stranik, O. Bergemann, C.; Grüttner, C.; Fritzsche, W.; Fischer, D. (2018). The hen´s egg test on the chick area vasculosa (HET-CAV) as a versatile alternative test system for iron oxide particles. 2nd NanoBEL Workshop, 07. March 2018, Jena, Germany. [Poster]
  • Rabel, M.; Warncke, P.; Thürmer, M.; Kurland, H-D.; Bergemann, C.; Grüttner, C.; Thamm, J.; Müller, F.A.; Koeberle, A.; Fischer, D. (2018). Biomolecule corona formation critically influences the toxicity and biodegradability of complex diagnostic nanoparticles. 22nd annual meeting CRS Germany Local Chapter, 01.-02. March 2018, Halle, Germany. [Oral]
  • Warncke, P., Rabel, M., Fischer, D. (2018). Role of polymer composition of PLGA-FexOy nanoparticles on biodegradation and protein corona formation. 22nd annual meeting CRS Germany Local Chapter, 01.-02. March 2018, Halle, Germany. [Poster]
  • Fischer, D. (2018). The life cycle of iron oxide nanoparticles: A preclinical test strategy. 2nd ISMAP 2018, 28. February 2018, Ilmenau, Germany. [Oral]
  • Warncke, P. (2018). Crack the egg: An alternative test system for the characterization of magnetic nanoparticles. 2nd ISMAP 2018, 28. February 2018, Ilmenau, Germany. [Oral]
 

2017

  • Warncke, P.; Pötzinger, Y.; Rabel, M.; Müller, R.; Stranik, O.; Fritzsche, W.; Fischer, D. (2017). The hen´s egg test on the chick area vasculosa (HET-CAV) as a versatile alternative test model to determine the biocompatibility of biomaterials. DGBM Annual Annual Meeting, 09.-11. November 2017, Würzburg, Germany. [Poster]
  • Fischer, D. (2017). Crack the egg - Versatile applications of a shell-less hen's egg model in pharmacy. DPhG Jahrestagung, 26-29. September 2017, Saarbrücken, Germany. [Oral]
  • Weyell, P.; Cialla-May, D.; Clement, J. H.; Fischer, D.; Grüttner, C.; Hilger, I.; Kurland, H.-D.; Müller, F. A.; Vornberger, A.; Bergemann, C.; Kralisch, D. (2017). Safe and benign by design concept for nanoparticles in medical applications. LCM2017 Conference, 03.-06. September 2017, Luxemburg, Luxemburg. [Oral]
  • Weyell, P.; Böhm, F.; Bergemann, C.; Grüttner, C.; Kurland, H.-D.; Müller, F. A.; Kralisch, D. (2017). Life cycle assessment of core-shell iron oxide nanoparticles for diagnostics. LCM2017 Conference, 03.-06. September 2017, Luxemburg, Luxemburg. [Poster]
  • Rabel, M.; Warncke, P.; Cialla-May, D.; Demut, J.; Thamm, J.; Bergemann, C.; Grüttner, C.; Clement, J. H.; Kurland, H.-D.; Müller, F. A.; Fischer, D. (2017). Pharmaceutically relevant assessment of the biodegradation of polysaccharide coated iron oxide nanoparticles. 5th EPNOE International Polysaccharide Conference 2017, 20.-24. August 2017, Jena, Germany. [Poster]
  • Rabel, M.; Warncke, P.; Thamm, J.; Kurland, H.-D.; Bergemann, C.; Grüttner, C.; Cialla-May, D.; Müller, F. A.; Fischer, D. (2017). The Life Cycle of Magnetic Nanoparticles: A Pharmaceutical Approach. 16th Ferrofluid Workshop, 17.-19. July 2017, Dresden, Germany. [Poster]
  • Demut, J.; Scheerer, P.; Grüttner, C.; Bergemann, C.; Müller, F.; Czerney, P.; Hochhaus, A.; Clement, J. H. (2017). Differentially charged SPIONs interfere with inflammation response during interaction with tumor cells. 16th Ferrofluid Workshop, 17.-19. July 2017, Dresden, Germany. [Poster]
  • Fischer, D. (2017). Nano in Pharma: Risiko, Perspektive oder nur Mythos?. Tag der Forschung: Pharmazie-Science First, 06. June 2017, Jena, Germany. [Oral]
  • Weyell, P.; Kralisch, D. (2017). Decision-making concept on medical nanoparticles. Discussion Forum on Life Cycle Assessment – DF65, 24. May 2017, Zürich, Switzerland [Oral]
  • Fischer D. (2017). Nano in der Apotheke: Risiko, Perspektive oder nur Mythos? Webinar Pharma4U, 23. May 2017. [Oral]
  • Fischer, D.; Kralisch, D.; Müller, F.A. (2017). NanoBEL: In vitro-Testsysteme zur Bewertung des Langzeitverhaltens von magnetischen Nanopartikeln im Organismus. NanoCare Clustertreffen 2017, 04.-05. May 2017, Eggenstein-Leopoldshafen, Germany. [Poster]
  • Vornberger, A. (2017). Lokalisierung von magnetischen Nanopartikeln in Zellen mittels Ramanspektroskopie. NanoCare Clustertreffen 2017, 04.-05. May 2017, Eggenstein-Leopoldshafen, Germany. [Poster]
  • Grüttner, C.; et al. (2017). Synthese von magnetischen Nanopartikeln mit Stealth-Polymeren und dualer Fluoreszenzmarkierung. NanoCare Clustertreffen 2017, 04.-05. May 2017, Eggenstein-Leopoldshafen, Germany. [Poster]
  • Clement, J.H.; Claus, R.; Romeike, B., Hilger, I. (2017). Degradationsverhalten von magnetischen Nanopartikeln in Zellen und lebenden Labortieren. NanoCare Clustertreffen 2017, 04.-05. May 2017, Eggenstein-Leopoldshafen, Germany. [Poster]
  • Cialla-May, D.; Patze, S.; Müller, R.; Weber, K.; Popp, J. (2017). Magnetische und optische Charakterisierung von Magnetit-Nanopartikeln. NanoCare Clustertreffen 2017, 04.-05. May 2017, Eggenstein-Leopoldshafen, Germany. [Poster]
  • Rabel, M.; Cialla-May, D.; Kurland, H.-D.; Thamm, J.; Bergemann, C.; Grüttner, C.; Müller, F.A.; Fischer, D. (2017). Assessing the biodegradation of complex diagnostic nanoparticles in artificial body fluids. 21st annual meeting CRS Germany Local Chapter, 02.-03. March 2017, Marburg, Germany. [Poster]
  • Weyell, P.; Cialla-May, D.; Clement, J.H.; Fischer, D.; Grüttner, C.; Hilger, I.; Kurland, H.D.; Szokup, S.; Bergemann, C.; Kralisch, D. (2017). A Concept for Decision Making on Innovative Iron Oxide Nanoparticles Selection for a Sustainable Application in Diagnostics. New Tools and Approaches for Nanomaterials Safety Assessment, 07.-09. February 2017, Malaga, Spain. [Oral]
  • Cialla-May, D.; Patze, S.; Müller, R.; Weber, K.; Popp, J. (2017). Optical and magnetic characterization of theranostic magnetite particles. Photonics West, 28. January - 2. February 2017, San Francisco, USA. [Oral]
 

2016

    • Clement, J.H. (2016). Magnetic nanomaterials meet biological barriers. Seminarreihe am Lehrstuhl für Pharmazeutische Technologie WS 2016/2017, 24. November 2016, Jena, Germany. [Oral]
    • Weyell, P.; Grüttner, C.; Kurland, H.D.; Müller, F.A.; Bergemann, C.; Kralisch, D. (2016). Criteria for decision making on innovative nanoparticle design for sustainable application in diagnostics. International Nano(bio)medicine Forum, 21. October 2016, Maynz, Germany. [Oral]
    • Demut J., Gräfe C., Hochhaus A., Clement, J.H. (2016). Multicellular spheroids: A model for nanoparticle-tumor cell interactions. Jahrestagung der Deutschen, Austriaischen und Schweizer Gesellschaften für Hämatologie und Medizinische Onkologie; 14.-18. October 2016, Leipzig, Germany. [Poster]
    • Weyell P., Kralisch D. (2016). Sustainable Nanotechnology for Diagnostics. Symposium der FSU: Nachhaltigkeit im interdisziplinären Diskurs – Theorien, Modelle, Praktiken, 12.-13. October 2016, Jena, Germany. [Oral]
    • Rabel, M.; Cialla-May, D.; Müller, R.; Kurland, H.-D.; Thamm, J.; Bergemann, C.; Grüttner, C.; Müller, F.A.; Fischer, D. (2016). Simulation of the biodegradation of iron oxide and iron oxide-silica nanoparticles in artificial body fluids. DPhG Annual Meeting 2016, 04.-07. October 2016, Munich, Germany. [Poster]
    • Warncke, P.; Müller, R.; Stranik, O.; Schlenk, F.; Werner, S.; Malsch, D.; Bergemann, C.; Fritzsche, W.; Fischer, D. (2016). The hen´s egg test as a model for optical detection of particle behavior under dynamic flow conditions. DPhG Annual Meeting 2016, 04.-07. October 2016, Munich, Germany. [Poster]
    • Weyell P., Böhm F., Kralisch D. (2016). Ganzheitliche Risiko- und Nachhaltigkeitsbewertung von Nanotechnologie für medizinische Anwendungen. Jahrestagung 2016: SETAC GLB, GDCh FG Umweltchemie und Ökotoxikologie, 5.-8. September 2016, Tübingen, Germany. [Poster]
    • Stauber R. (2016). The biocorona: Lessons learned and challenges accepted. International Nanotoxicology Congress, 1.-4. June 2016, Boston, USA. [Oral]
    • Fischer D. (2016). Nano in der Apotheke: Risiko, Perspektive oder nur Mythos?. Deutsche Pharmazeutische Gesellschaft, Oralsreihe: 26. April 2016, Dessau; 12. May 2016, Berlin; 26. May 2016 Magdeburg; 01. June 2016, Halle, Germany; 02. November 2016, Regensburg, Germany; 13. December 2016, Tübingen, Germany. [Oral]
    • Kögler C., Engelhardt J., Röhrig N., Wurzbach P., Hilger I. (2016). Joint Project on Biological elimination of complex diagnostic nanoparticles – NanoBEL. 8th Postgraduate Symposium on Cancer Research, 23. April 2016, Dornburg, Germany. [Poster]
    • Johl A., Grüttner C., Müller K. (2016). Synthese von magnetischen Nanopartikeln (MNP) mit Stealth-Polymeren und dualer Fluoreszenzmarkierung. Clustertreffen NanoCare, 3.-4. May 2016, Frankfurt am Mayn, Germany. [Poster]
    • Bergemann C., Öztürk C. (2016). Dual-fluoreszierende magnetische Nanopartikel für die intrazelluläre Analytik. Clustertreffen NanoCare, 3.-4. May 2016, Frankfurt am Mayn, Germany. [Poster]
    • Fischer D., Kralisch D., Müller F., Clement J.H. (2016). NanoBEL: in vitro-Prädiktionsmodelle zur Bewertung der biologischen Elimination komplexer diagnostischer Nanopartikel. Clustertreffen NanoCare, 3.-4. May 2016, Frankfurt am Mayn, Germany. [Poster]
    • Szokup S. (2016). Bestimmung von chemischen und strukturellen Eigenschaften magnetischer Nanopartikel-Suspensionen. Clustertreffen NanoCare, 3.-4. May 2016, Frankfurt am Mayn, Germany. [Poster]
   

2015

  • Docter D. (2015). Impact of the Nanomaterial Biomolecule Corona for Biomedical Applications. NANOBIOAPP2015, 21.-23. September 2015, Barcelona, Spain. [Oral]
  • Fischer, D. (2015). Nano in der Apotheke: Risiko, Perspektiven oder nur Mythos?. Deutsche Pharmazeutische Gesellschaft, 09.11.2015, Koblenz, Germany. [ORAL]
  • Fischer, D. (2015). Nano in der Apotheke: Risiko, Perspektiven oder nur Mythos?. Deutsche Pharmazeutische Gesellschaft und Landesapothekerkammer, 07. July 2015, Jena, Germany. [ORAL]
 

  • Sicherheit in der Nano-Medizin, Pressebeitrag zum NanoBEL-Workshop, Ostthüringer Zeitung, 03. März 2018
  • Ausgewählt: Beim Tag der Forschung an der Jenaer Uni wurde der Fokus auf die Pharmazie gelegt. Jena TV - Video-Beitrag 07.06.2017.
  • Nanopartikel im Frühstücksei - Forscher der FSU untersuchen in neuem Großprojekt die Langzeiteffekte von magnetischen Nanopartikeln auf den menschlichen Körper, Pressemeldung Universität Jena, 24.06.2015, (uni-jena.de).
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