> 
nanoGRAVUR : nanostructured materials – grouping for occupational health, consumer and environmental protection and risk mitigation
Nanotechnology offers numerous new applications in various areas of industry (e.g., in the chemical industry, electrical engineering, and medical engineering). The specific challenge lies in the optimal use of the potentials of these partially new technologies and, at the same time, in their responsible handling.
Scheme for the derivation of criteria catalogues (K) for different protected assets based on the risk-determining factors nanomaterial properties (N) release / exposure (Exp) and hazard (H and Eco).
In view of the large variety of existing synthetic nanomaterials, some of which have been used for decades in conventional products and most of which, besides, are available in numerous modifications (different sizes, shapes, chemical composition, and surface functionalisation), the effort of analysing their behaviour and effects while observing specific regulatory requirements is tremendous. Regarding the variability of possible effects, it is, in addition, impossible, to assess the potential risk for each individual nanomaterial.
The current state of knowledge on the hazard of nanomaterials towards protected assets is so complex that the nanoGRAVUR project made it its central objective to develop different criteria catalogues for a grouping of nanomaterials according to the respective potentials for exposure, hazard and risk. The grouping approach, which so far has been used only in special cases (e.g. for fibres), can, among other things be used in areas such as occupational health and safety, product identification, and regulation, which presently still must rely on individual case studies.
Project Website (in German): www.iuta.de/nanogravur/
Grant Number: BMBF - 03XP0002
Duration: 01.05.2015 - 30.04.2018 (extented to 30.06.2018)
Project Lead
Institute of Energy and Environmental Technology e.V. (IUTA), Duisburg (DE)
Prof. Dr. Thomas Kuhlbusch, German Federal Institute for Occupational Safety and Health (BAuA), Dortmund (DE)
Project Partners
German Federal Institute for Occupational Safety and Health (BAuA), Dortmund (DE)
https://www.baua.de/EN/Home/Home_node.html
https://www.baua.de/EN/Home/Home_node.html
German Federal Institute for Risk Assessment (BfR), Berlin (DE)
https://www.bfr.bund.de/en/home.html
https://www.bfr.bund.de/en/home.html
Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) - Division Schmallenberg (IME), Schmallenberg (DE)
https://www.ime.fraunhofer.de/en.html
https://www.ime.fraunhofer.de/en.html
Department Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research (UFZ), Leipzig (DE)
https://www.ufz.de/index.php?en=34241
https://www.ufz.de/index.php?en=34241
IBE R&D Institute for Lung Health gGmbH, Münster (DE)
https://www.technologiefoerderung-muenster.de/unternehmen/ibe-rd-ggmbh
https://www.technologiefoerderung-muenster.de/unternehmen/ibe-rd-ggmbh
Institute for Occupational Safety and Health (IFA), German Social Accident Insurance (DGUV), Sankt Augustin (DE)
https://www.dguv.de/ifa/index-2.jsp
https://www.dguv.de/ifa/index-2.jsp
Biomedical Technology Center of the Medical Faculty Muenster, University of Muenster, Muenster (DE)
https://www.medizin.uni-muenster.de/en/faculty-of-medicine/welcome.html
https://www.medizin.uni-muenster.de/en/faculty-of-medicine/welcome.html
Institute of Process Engineering and Environmental Technology (IVU), TU Dresden (TUD), Dresden (DE)
https://tu-dresden.de/ing/maschinenwesen/ifvu/mvt?set_language=en#
https://tu-dresden.de/ing/maschinenwesen/ifvu/mvt?set_language=en#
Publications
2019
- Kühnel D., Nickel C., Hellack B., Van Der Zalm E., Kussatz C., Herrchen M., Meisterjahn B., Hund-Rinke K. (2019). Closing gaps for environmental risk screening of engineered nanomaterials. NanoImpact, 15. DOI: 10.1016/j.impact.2019.100173
- Schwirn K., Völker D. (2019). Hazard grouping of nanomaterials for daphnia and algae toxicity: lessons learned from scientific projects for regulatory applicability. Environmental Sciences Europe, 31(1): DOI: 10.1186/s12302-019-0226-9
- Wohlleben W., Hellack B., Nickel C., Herrchen M., Hund-Rinke K., Kettler K., Riebeling C., Haase A., Funk B., Kuhnel D., Gohler D., Stintz M., Schumacher C., Wiemann M., Keller J., Landsiedel R., Brossell D., Pitzko S., Kuhlbusch T.a.J. (2019). The nanoGRAVUR framework to group (nano)materials for their occupational, consumer, environmental risks based on a harmonized set of material properties, applied to 34 case studies. Nanoscale, 11(38): 17637-17654. DOI: 10.1039/c9nr03306h
2018
- Wiemann M., Sauer U.G., Vennemann A., Backer S., Keller J.G., Ma-Hock L., Wohlleben W., Landsiedel R. (2018). In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO(2). Nanomaterials (Basel), 8(3):
- Hund-Rinke K., Schlich K., Kühnel D., Hellack B., Kaminski H., Nickel C. (2018). Grouping concept for metal and metal oxide nanomaterials with regard to their ecotoxicological effects on algae, daphnids and fish embryos. NanoImpact, 9 52-60.
2017
- Gandon A., Werle K., Neubauer N., Wohlleben W. (2017). Surface reactivity measurements as required for grouping and read-across: An advanced FRAS protocol. J Phys: Conf Series, 838 012033.
- Landsiedel R., Ma-Hock L., Wiench K., Wohlleben W., Sauer U.G. (2017). Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping. J Nanopart Res, 19(5): 171.
Alle verfügbaren Abschlussberichte des nanoGRAVUR Konsortiums finden Sie auf den Seiten der TIB Hannover https://www.tib.eu/de/
- Institut für Energie- und Umwelttechnik e.V. (IUTA)
- BASF SE
- Zoz GmbH
- Bundesinstitut für Risikobewertung (BfR)
- Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA)
- Umweltbundesamt (UBA)
- Berufsgenossenschaft Rohstoffe und Chemische Industrie (BG RCI)
- Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie (IME) (2018). Nanostrukturierte Materialien - Gruppierung hinsichtlich Arbeits-, Verbraucher- und Umweltschutz und Risikominimierung - nanoGRAVUR : Teilaspekt: Verbleib und Wirkung in der Umwelt : Abschlussbericht. FKZ 03XP0002H, TIB Hannover. (DOI)
- Helmholtz-Zentrum für Umweltforschung GmbH (UFZ)
- IBE R&D Institute for Lung Health gGmbH
- Deutsche Gesetzliche Unfallversicherung e. V. (DGUV) Institut für Arbeitsschutz (IFA)
- Westfälische Wilhelms-Universität Münster
- Technische Universität Dresden
2017
- Kühnel, Dana; Esther van der Zalm, Carola Kussatz, Kathrin Schwirn, Kerstin Hund-Rinke (2017). Grouping of nanomaterials regarding their ecotoxicity – the ECOTOX tool. Scientific Stakeholder Meeting, 10-11 Oktober 2017 Dessau, Deutschland. [Poster]
- Kühnel, Dana; Carola Kussatz, Esther van der Zalm, Kathrin Schwirn, Doris Völker, Kerstin Hund-Rinke (2017). Grouping/Read Across approaches to reduce the testing of nanomaterials regarding their environmental hazard. Scientific Stakeholder Meeting, 10-11 Oktober 2017 Dessau, Deutschland. [Vortrag]
- Broßell, Dirk; Sabine Plitzko, Christian Schumacher (2017). The shaker dustiness test for high aspect ratio materials. Workshop JRC Ispra, 28-29 June 2017, Ispra, Italien. [Vortrag]
- Kuhlbusch, Thomas and the nanoGRAVUR Team (2017). Nanostructured materials – Grouping in view of worker, consumer and environmental safety and risk minimization. Workshop JRC Ispra, 28-29 June 2017, Ispra, Italien. [Vortrag]
- Möhlmann, Carsten; Christian Schumacher, Bianca Oeffling (2017). Grouping of exposure to nano objects and risk in workplaces. Workshop JRC Ispra, 28-29 June 2017, Ispra, Italien. [Vortrag]
- Wohlleben, Wendel; Robert Landsiedel, Martin Wiemann, Karin Wiench (2017). A Multi-Assay Implementation of the ECETOC Grouping Framework: Dissolution, Reactivity and Cellular Effects. Workshop JRC Ispra, 28-29 June 2017, Ispra, Italien. [Vortrag]
- Wohlleben, Wendel (2017). Grouping of nanomaterials: The value of extrinsic properties, of lifecycle transformation and release behaviour. Harvard School of Public Health, 28.06.2017, Boston MA, USA. [Vortrag]
- Wohlleben, Wendel (2017). Identification and hazard grouping of nanomaterials by intrinsic and extrinsic properties. NIOSH, 26.06.2017, Morgantown WV, USA. [Vortrag]
- Wohlleben W., KellerJ., Werle K., Hellack B., Nickel C., Koltermann J., Wiemann M. (2017). Multi-assay implementation of the ECETOC grouping framework: Reactivity & dissolution results on families of pigments & silicates. NanOEH 2017, 29.05-01.06.2017, Helsingore, Dänemark. [Vortrag]
- Kühnel, Dana; Esther van der Zalm, Carola Kussatz, Kathrin Schwirn, Kerstin Hund-Rinke (2017). Grouping of nanomaterials regarding their ecotoxicity – are hypotheses based on literature data robust enough? SETAC, 7-11 May 2017, Brüssel, Belgien. [Poster]
- Hund-Rinke K., E. van der Zalm, K. Schwirn, C. Kussatz, D. Kühnel (2017). Überprüfung von Gruppierungshypothesen zur ökotoxikologischen Wirkung von NM. DaNa Clustertreffen, 4-5 Mai 2017, Karlsruhe, Deutschland. [Poster]
- Wohlleben, W. (2017). Keynote: Release of nanomaterials from products: news on the quest for nano-resonances. NanoImpact Conference, 12.-17.03.2017, Monte Verita, Schweiz. [Vortrag]
2016
- Riebeling C., Wiemann M., Kuhlbusch T.K.J., Hellack B., Luch A., Haase A., Landsiedel R., Wohlleben W. (2016). Surface reactivity as criterion for grouping and read-across. NanoSafe 2016, 7.-9.11.2016, Grenoble, Frankreich. [Vortrag]