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A German Initiative on the Health Aspects of Synthetic Nanoparticles:

Establishing an Information- and Knowledge-Base for Innovative Material Research

The NanoCare project (running from 2006 until 2009) aimed at broadening the knowledge about synthetic nanomaterials with regard to the potential impacts of nanomaterials on human health. New innovative applications and measurement methods were developed for a sustainable and caretaking use of chemical nanotechnology.

Data created within NanoCare were interpreted together with additional information from literature and then published by the “knowledgebase”. This publication of nanotechnology safety aspects satisfied increasing information needs of the public. Furthermore, the results were presented to and discussed with the interested public, politicians and NGOs at dialogue events. Partners from industry, universities and research institutes were contributing their expertise to this partnership.

Grant Number: BMBF - FKZ 03X0021
Duration: 01.03.2006 - 31.07.2009

Project Lead

Forschungszentrum Karlsruhe (FZK) Logo
Prof. Dr. Harald Krug, Forschungszentrum Karlsruhe GmbH (seit März 2009 Empa, St. Gallen, Schweiz) (03/2006 - 02/2009)
PD Dr. Thomas Kuhlbusch, Institut für Energie- und Umwelttechnik e.V. (IUTA) (03/2009 - 07/2009)

Web Coordination

Dr. Katja Nau, Forschungszentrum Karlsruhe GmbH (seit 2009 Karlsruher Institut für Technologie - KIT)

Project Partners

Forschungszentrum Karlsruhe (FZK) Logo
Forschungszentrum Karlsruhe GmbH
Institut für Energie- und Umwelttechnik e.V. (IUTA)
BASF Logo gruen Product Safety
nanoMAT Logo
ayer Material-Science Logo
Bayer MaterialScience
Dechema Logo
Evonik Logo
IBE R&D Institute for Lung Health gGmbH Logo
IGF Logo Deutsch
Institut für Gefahrstoff-Forschung (IGF)
ItN Nanocation Logo
ItN Nanovation
Solvay Logo
SusTech Logo
SusTech Darmstadt
Bielefeld Universität Logo
University of Bielefeld
Saarland University Logo
Saarland University
VDI Technologiezentrum Logo
VDI Technologiezentrum
University pf Muester (WWU) Logo
University of Münster



  • Interference of engineered nanoparticles with in vitro toxicity assays. Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Arch Toxicol, 86(7): 1123-1136..
  • Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays. Kroll A,  Dierker C, Rommel C, Hahn D, Wohlleben W, Schulze-Isfort C, Göbbert C, Voetz M, Hardinghaus F, and Schnekenburger J Part Fibre Toxicol, 8(1): 9.


  • Interaction of metal oxide nanoparticles with lung surfactant protein A. Schulze C, Schaefer UF, Ruge CA, Wohlleben W, Lehr CM. Eur J Pharm Biopharm, 77(3): 376-383. Testing Metal-Oxide Nanomaterials for Human Safety Landsiedel R, Ma-Hock L, Kroll A, Hahn D, Schnekenburger J, Wiench K, Wohlleben W. 2010 Adv Mater, 22(24): 2601-2627.
  • Investigation of airborne nanopowder agglomerate stability in an orifice under various differential pressure conditions Stahlmecke B, Wagener S, Asbach C, Kaminski H, Fissan H, Kuhlbusch, TA J. 2009 J Nanopart Res, 11(7): 1625-1635.
  • Comparison of four mobility particle sizers with different time resolution for stationary exposure measurements. Asbach C, Kaminski H, Fissan H , Monz C, Dahmann D,  Mülhopt S, H-R Paur, Kiesling HJ, Herrmann F, Voetz M, Kuhlbusch TAJ. 2009 J Nanopart Res 11(7): 1593-1609.
  • The NanoCare project: a German initiative on health aspects of synthetic nanoparticles Nau K, Krug HF. 2009 Journal of Physics: Conference Series, 170(1): 012038.
  • Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size. Pauluhn J. 2009 Toxicol Sci, 109(1): 152-167.
  • Genotoxicity Investigations on Nanomaterials: Methods, Preparation and Characterization of Test Material, Potential Artifacts and Limitations - Many Questions, Some Answers. Landsiedel R, Schulz M, Kapp MD, Oesch F. 2009 Mutat Res, 681(2-3): 241-258.
  • Current in vitro methods in nanoparticle risk assessment: Limitations and challenges Kroll A, Pillukat MH, Hahn D, Schnekenburger J. 2009 Eur J Pharm Biopharm, 72(2): 370-377.
  • Development of a short-term inhalation test in rats using nano-titanium dioxide as a model substance. Ma-Hock L, Burkhardt S, Strauss V, Gamer A, Wiench K, van Ravenzwaay B, Landsiedel R. 2009 Inhal Toxicol, 21(2): 102-118.



  • Generation and Characterization of Test Atmospheres with Nanomaterials. Ma-Hock L, Gamer A, Landsiedel R, Leibold E, Frechen T, Sens B, Huber G, van Ravenzwaay B. 2007 Inhal Toxicol, 19(10): 833-848..

NanoCare Abschlussbericht Titelbild Wissenschaftlicher Abschlussbericht, Juli 2009 (englisch): Health related Aspects of Nanomaterials Final Scientific Report (PDF, 19 MB) NanoCare Broschuere TitelbildNanoCare-Broschüre , 2009 Gesundheitsrelevante Aspekte synthetischer Nanomaterialien (PDF, 2,6 MB)

Bürgerdialog: "Nanotechnologie sicher gemacht"

29. November 2008 Dresden, Japanisches Palais Flyer zur Veranstaltung (Dresden)  (234 KB)

Bürgerdialog: "Gesundheitliche Wirkungen von Nanopartikeln"

27. September 2008 München, Deutsches Museum Flyer zur Veranstaltung (München)  (234 KB)

Bürgerdialog: "Sichere Herstellung von Nanomaterialien"

12. April 2008 Hamburg, Hauptgebäude der Universität Flyer zur Veranstaltung (Hamburg)  (855 KB)

16.-17. Juni 2009 in Berlin, Jerusalemkirche: Programm



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