>
Spotlight May 2022: Nano-ghosts” – Risk assessment of submicron-sized particles in food biased towards fictional “nano”
The European Commission has issued a ban on the colorant titanium dioxide in food. Titanium dioxide, which provides a nice shine and bright white color, can potentially damage genetic material.
We chose a review article from 2022 for the May 2022 Spotlight that addresses the risk assessment of food-grade titanium dioxide (E171) and the resulting potential bias against nanoscale titanium dioxide.
The authors are not interested in avoiding a ban on the use of E171 in food. Rather, it is important that the same bias against a fictitious “nano” hazard be avoided in the future.
The E171 case illustrates how the risk assessment of manufactured particulate food additives is potentially biased toward a supposed nanoscale particle hazard.
The authors summarize that, for example, subacute studies show that oral exposure to E171 does not cause toxicity in rodents or that chronic toxicity studies show that oral exposure to E171 does not cause carcinogenicity or other long-term adverse effects in rodents, even when tested at high doses.
The objective of this review is to reassess the literature on the toxicity of titanium dioxide particles, focusing on studies that are directly relevant to the evaluation of E171.
Original Publication:
Naegeli, H. and C. Gsell (2022). „“Nano-ghosts“: Risk assessment of submicron-sized particles in food biased towards fictional „nano“. EXCLI J 21: 279-299.
Weitere Spotlights
Spotlight February 2023: New sustainable and promising method to give cotton textiles an antiviral and antibacterial finish
Textiles have been the subject of research into functionalization for many years, especially also to repel bacteria and viruses. Since the development of nanotechnological processes, there have been many attempts to incorporate UV protection with nano-titanium dioxide, or to provide textiles with anti-bacterial properties with nanosilver (see cross-sectional text “Nanoparticles in Textiles”). But nanosilver has […]
Read moreSpotlight November 2021: Safe Materials from Scratch – Safe-by-Design in Materials Research
Advances in the field of materials science continue to amaze us with nanoscale materials with extraordinary chemical, electrical, optical, and numerous other properties. However, some nanoscale materials have different toxicological profiles compared to the same bulk material. Since safety issues are usually addressed just before launching a product into the market, safety issues may be […]
Read moreSpotlight September 2020: Groundwater remediation with Carbo-Iron® – Risk or Benefit?
In September we would like to present a paper of the BMBF project Fe-Nanosit. The project dealt with the use of iron-containing nanomaterials in groundwater and wastewater remediation. A comprehensive assessment and weighing of benefits and possible environmental risks resulting from the application is now presented by the project partners in this paper. Groundwater is indispensable for the […]
Read moreSpotlight February 2022: Probabilistic risk assessment – the keystone for the future of toxicology
The basics of toxicology are constantly being reconsidered, and the approach to risk assessment is therefore constantly being put to the test, because, as William Osler is cited in this publication, “Medicine (toxicology) is a science of uncertainty and an art of probability“. In this recent paper, the team around Thomas Hartung (Johns-Hopkins University/University of […]
Read more