
Advances in the field of materials science continue to amaze us with nanoscale materials with extraordinary chemical, electrical, optical, and numerous other properties. However, some nanoscale materials have different toxicological profiles compared to the same bulk material. Since safety issues are usually addressed just before launching a product into the market, safety issues may be discovered too late, thus resulting in a lot of wasted effort. This month we want to highlight a two-part research paper. This paper proposes a Safe-by-Design (SbD) strategy to link materials functionality with environmental and human safety allowing innovators to anticipate potential safety issues in the early stages of the innovation process. Therefore, unleashing the full economic potential of innovative nanoscale materials.
The SbD strategy aims to reduce uncertainties in materials research and development and, at the same time, raise human and environmental safety. The proposed strategy ensures the collection of safety-related data throughout the whole development process complying with regulatory requirements and ensuring a transparent communication of risks from early in the innovation process onwards. The authors adapt the Cooper’s stage-gate-model – a project management technique usually used for product development – by including new decisive parameters for the decision-making during the innovation process. Moreover, the authors offer a comprehensive overview of the information needed to balance safety and functionality and illustrate the applicability of the SbD strategy using a case study: Carbon nanotube-based transparent conductive films. Whereas the second part of the paper concentrates on the applicability of SbD, the first part offers a set of questions to identify which type of information is required to assess and reduce environmental and human risks. These questions allow innovators to find, prioritize, and choose safer alternatives.
Original publications:
Tavernaro, I., Dekkers, S., Soeteman-Hernández, L. G., Herbeck-Engel, P., Noorlander, C., and Kraegeloh, A. 2021. Safe-by-design part II: a strategy for balancing safety and functionality in the different stages of the innovation process. NanoImpact, 24, 100354. DOI: 10.1016/j.impact.2021.100354
Dekkers, S., Wijnhoven, S. W., Braakhuis, H. M., Soeteman-Hernandez, L. G., Sips, A. J., Tavernaro, I., Kraegeloh, A., and Noorlander, C. W. 2020. Safe-by-Design part I: Proposal for nanospecific human health safety aspects needed along the innovation process. NanoImpact, 18, 100227. DOI: 10.1016/j.impact.2020.100227

Weitere Spotlights
Spotlight April 2022: A new risk assessment of nanomaterials in 3D printing is needed
The use of nanomaterials in 3D printing has great potential. Due to the properties of nanoscale materials, many requirements can be implemented in 3D printing. However, these unique properties based on the size of the particles also lead to the need for new risk assessments. This is because if the nanoparticles are released in the […]
Read moreSpotlight April 2021: Nanomaterials and Fake News – a commentary based on an example
In February 2021, the article “The invisible killer lurking in our consumer products” appeared, describing nanoparticles as a greater danger than Corona [1]. “The use of nanomaterials” would be “unregulated” and “nanomaterials are so small that they cannot be determined once they are part of a product”. So what is the truth of these statements? […]
Read moreSpotlight September 2021: Wood, the raw material of the future?
One of the greatest challenges facing humanity is to produce clean drinking water under the given circumstances of global warming, population growth and increasing littering. In September, we would like to present a review article that believes one approach to solve this problem is the use of nanoscale wood. In the review, “Advanced Nanowood Materials […]
Read moreSpotlight August 2023: From principles to reality. FAIR implementation in the nanosafety community
In the August 2023 Spotlight, we present a paper that addresses the implementation of FAIR (Findability, Accessibility, Interoperability and Reusability) Data in nanosafety research. The authors introduce the new AdvancedNano GO FAIR Implementation Network (see also https://www.go-fair.org/implementation-networks/overview/advancednano/) established as part of the GO FAIR initiative. The paper highlights the AdvancedNano GO FAIR Implementation Network’s support […]
Read more