
The smallest particles in materials research, nanoparticles, have occupied us intensively for more than 20 years to elucidate and further investigate their safety for humans and the environment. Now, however, the development is going from “small = nano” to “clever = advanced”, as discussed in a contribution by international scientists. Thereby, it is a great advantage to learn directly from the developments and achievements in the safety research of nanomaterials or to be able to transfer and apply them to advanced materials as well. In addition to the question “What is actually advanced or smart”, the demand for “Safe and sustainable by design (SSbD)” is also raised and the associated challenges are addressed. Important criteria for research here are the possibilities of characterizing the object of investigation, i.e. the concrete description of an advanced material, as well as the quality of the data generated and the data management. Again, the need for close collaboration between scientists from different disciplines with other stakeholders such as industry or regulatory authorities is pointed out. The authors make the important observation that nanosafety research to date has provided and will further provide the tools to meet this new challenge as well.
In doing so, they draw attention to three important prerequisites:
- The extension from “nano” to “advanced materials” should be based on technical criteria and include modelling as well as grouping approaches.
- Furthermore, sustainability should be integrated into the new material designs.
- And finally, these two principles should be firmly anchored in research, innovation and regulation to ensure a smooth transition to the implementation of the new and innovative materials.
Original publication:
Valsami-Jones, E et al. (2022). From small to clever: What does the future hold for the safety and sustainability of advanced materials? Nano Today, 42

Weitere Spotlights
Spotlight February 2022: Probabilistic risk assessment – the keystone for the future of toxicology
The basics of toxicology are constantly being reconsidered, and the approach to risk assessment is therefore constantly being put to the test, because, as William Osler is cited in this publication, “Medicine (toxicology) is a science of uncertainty and an art of probability“. In this recent paper, the team around Thomas Hartung (Johns-Hopkins University/University of […]
Read moreSpotlight July: Plastic Pollution and the Urgent Need for Comprehensive Action
Plastic pollution has become a significant threat to the oceans, biodiversity, and ecosystems worldwide. Despite efforts to reduce plastic consumption, escalating plastic production continues to increase the magnitude of plastic pollution in the environment. In response to this crisis, the UN-Environmental Assembly (Link) adopted a resolution in March 2022 to develop a legally binding treaty […]
Read moreSpotlight January 2022: Methods, models, mechanisms and metadata
For the new year, we are presenting no “classic” paper here, but would like to point out an editorial: Methods, Models, Mechanisms and Metadata: Introduction to the Nanotoxicology Collection at F1000 Research. This editorial introduces the F1000Research Nanotoxicology Collection, where best practices can be collected in the form of original research reports, including no-effect studies, […]
Read moreSpotlight August 2022: Three-stage model for the formation of micro- and nanoplastic particles.
Plastic pollution is a global problem that will continue to affect humanity for more than 100 years. There is the visible pollution, e.g. plastic debris in the environment, which leads to death for many animals (because they mistakenly think the plastic is food and eat it or because they get caught in the plastic waste). […]
Read more