>
Spotlight October 2022: The titanium dioxide debate – why the current ECHA and EFSA hazard classification should be questioned
Due to various reports and scientific studies, titanium dioxide (TiO2)was also banned in Europe this year (2022) for use as a food additive with the indication that it could possibly be carcinogenic to humans. Although no case of tumour induction in humans has been reported since the use of this material in micro but also nano size in many products (included in paints as a white pigment for more than 80 years and permitted in foodstuffs in Europe since 2008) the European Chemicals Agency (ECHA) and the European Food Safety Authority (EFSA) have concluded that the evidence would be sufficient to apply a new classification.
However, the British Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COC) and Health Canada disagree and continue to classify TiO2 as harmless because they consider the evidence from the submitted reports to be inconclusive and inapplicable.
The two here presented recent publications now comment on this new classification in Europe and come to the conclusion that this classification must be reconsidered, as there is no evidence for such a direct genotoxic effect of TiO2 in consumer products, would thus follow the British and Canadian example. The example of TiO2 makes it clear how important it is in the future to carry out toxicological tests exactly according to protocol and thus produce high-quality and comprehensible “FAIR” results (cf. Spotlights September 2022 and August 2021).
Original publications:
- Driscoll, K.E. (2022). Review of Lung Particle Overload, Rat Lung Cancer, and the Conclusions of the Edinburgh Expert Panel-It’s Time to Revisit Cancer Hazard Classifications for Titanium Dioxide and Carbon Black. Front Public Health 10, 907318
- Kirkland, D., Aardema, M.J., Battersby, R.V., Beevers, C., Burnett, K., Burzlaff, A., Czich, A., Donner, E. M., Fowler, P., Johnston, H.J., Krug, H.F., Pfuhler, S., Stankowski, L.F. (2022). A weight of evidence review of the genotoxicity of titanium dioxide (TiO₂). Regulatory Toxicology and Pharmacology, in press, journal pre-proof
Weitere Spotlights
Spotlight December 2022: Fighting tumors with micro robots
When we, the DaNa team as operators of the website nanopartikel.info, write about nanobots, i.e. nanometre-sized machines, we point out that these machines belong to science fiction, may even remain a utopia – i.e. never realisable. On the significantly larger micro-scale, however, small machines are conceivable that could help in the therapy of diseases, e.g. […]
Read moreSpotlight September 2020: Groundwater remediation with Carbo-Iron® – Risk or Benefit?
In September we would like to present a paper of the BMBF project Fe-Nanosit. The project dealt with the use of iron-containing nanomaterials in groundwater and wastewater remediation. A comprehensive assessment and weighing of benefits and possible environmental risks resulting from the application is now presented by the project partners in this paper. Groundwater is indispensable for the […]
Read moreSpotlight December 2020: Rethinking Nanosafety – Part II
In December we would like to draw attention to the special issue: Rethinking Nanosafety – Part II in small. In the July Spotlight we already presented Part I. This special issue “Rethinking Nanosafety – Part II” also features research papers by renowned scientists in the field of nanosafety research. The first part of this special […]
Read moreSpotlight March 2022: Safe Materials from Scratch – Safe-by-Design-Concept in action
In recent decades, German research on nanomaterials and new, innovative materials has been widely expanded by material safety aspects. European initiatives also pay significant attention to this: both the European Union (EU) Green Deal, and the Chemicals Strategy for Sustainability (CSS) aim to create a sustainable, climate-neutral economy with sustainable and safe chemicals and products, […]
Read more