An in vitro study of phagocytosing immune cells in the brain (microglial cells) has revealed that titanium dioxide (TiO2) nanoparticles can trigger oxidative stress in these cells [1].


Given the fact that the blood-brain barrier is a good protection against penetration of pathogens, it remains to be found out whether or not at all TiO2 particles can get into the brain. Besides passing the blood-brain barrier, particles, when inhaled, can get directly into the brain via the olfactory nerve.

In a study with rats, no increased amounts of TiO2 nanoparticles were found in the brains after injection into the bloodstream [2]. No titanium was detected in the brains of mice after instillation with TiO2[3].



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