The uptake behaviour of diamond nanoparticles was studied in different human cell lines and brain cells of rats.

 

A consistent uptake of particles of different sizes into the cells was confirmed using electron microscopy [1,2]. The uptake of the particles takes place as an active process through endocytosis (see our article "basics - behaviour"). The particles accumulate in certain cell organelles, presumably lysosomes [3].

Nanodiamonds have the capacity to be strongly fluorescent and have therefore been used in many studies as cell-penetrating "dyes" [3,4,5,6,7,8]. Generally, nanodiamonds are rapidly absorbed (within minutes) by living cells [8,9].

 

Literature arrow down

  1. INOS Scientific Reports (see Publications of the Project INOS)
  2. Busch, W et al. (2011), J Nanopart Res, 13(1): 293-310.
  3. Faklaris, O et al. (2009), ACS Nano, 3(12): 3955-3962.
  4. Cheng, CY et al. (2007), Appl Phys Lett, 90(16): 163903.
  5. Fu, CC et al. (2007), PNAS, 104(3): 727-732.
  6. Ho, DA (2009), ACS Nano, 3(12): 3825-3829.
  7. Takimoto, T et al. (2010), Chem Mater, 22(11): 3462-3471.
  8. Neugart, F et al. (2007), Nano Lett, 7(12): 3588-3591.

 

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