Silver nanoparticles can be taken up into cells.

Possible uptake mechanisms for silver nanoparticles. © Eckhardt et al. (2013), Chem Rev, 113(7): 4708-4754.Possible uptake mechanisms for silver nanoparticles. © Eckhardt et al. (2013), Chem Rev, 113(7): 4708-4754.

 

Uptake of silver nanoparticles in the cells has been proved within the framework of in vitro studies. (Nano)particles or small agglomerates are usually taken up via phagocytosis or pinocytosis and can be detected in intracellular vesicles. In phagocytes receptors, so-called scavenger receptors, mediate the cellular uptake processes of the nanoparticles.

 

Using techniques such as electron microscopy has enabled the detection of silver nanoparticles in membrane-enclosed structures (vesicles) after the uptake into the cell. Due to the acidic pH within the vesicles, the silver nanoparticles are dissolved and silver ions released into the cytoplasm, which in turn can initiate the generation of oxidative stress, inflammation and toxicity. Researchers have described this mode of action as a "Trojan Horse" mechanism.[1-5]

 

 

Literature arrow down

  1. Gaiser, BK et al. (2013). Toxicol Sci, 131(2): 537-547.
  2. Gliga, AR et al. (2014). Part Fibre Toxicol, 11(1): 11.
  3. Luther, EM et al. (2011). Nanotechnology, 22(37): 375101.
  4. Singh, RP et al. (2012). Toxicol Lett, 213(2): 249-259.
  5. Verano-Braga, T et al. (2014). ACS Nano, 8(3): 2161-2175.

 

 

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