To date, only little is known about the uptake of carbon nanotubes (CNTs) from the blood into the brain across the so-called blood-brain barrier (cross-cutting - nanoparticles at the blood-brain barrier).


Up to now, only one single study described the detection of very small amounts of unmodified, water-insoluble carbon-nanotubes in the brain of laboratory animals after CNT injection into the bloodstream. This observation indicates the ability of carbon nanotubes to cross the blood-brain barrier under certain conditions [1].Preparation of injectable medicines. © sudok1 /


However, to date no validation of this distribution-behaviour has been published. Furthermore, the study applied relatively high doses of CNTs and did not describe in detail the analysis of the brain-tissue. It is quite conceivable that small bundles of CNTs were located within the brain-capillaries and therefore assigned to the brain without ever having left the vessels.

It remains to be seen whether other studies can confirm this behaviour and under which conditions a transfer of carbon nanotubes from the bloodstream into the brain is possible. Once identified, this mode of action could have positive (e.g. drug administration in the brain) as well as negative effects (e.g. cell death, brain damage), which still needs to be studied in more detail.





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